Bladder cancer talk, slides with references, with quoted research and links

Bladder cancer

Proper Nutrition
“It is biologically plausible for dietary factors to influence
bladder cancer risk considering that beneficial as well as
harmful components of a diet are excreted through the urinary
tract and in direct contact with the epithelium of the bladder.”
“A diet rich in fruits and vegetables and low in processed
meat along with especially smoking cessation may convey
some protective effects against bladder cancer risk.”
Deficiencies caused by smoking: Vitamin C, Vitamin A,
Glutathione

Investigative and Clinical Urology

https://www.ncbi.nlm.nih.gov/pubmed/27326403

Vegetables and Bladder Cancer
“Our data strongly support that high vegetable
consumption, especially cruciferous vegetable intake,
may protect against bladder cancer”

Cancer Epidemiology, Biomarkers and Prevention

https://www.ncbi.nlm.nih.gov/pubmed/19549811

“Epidemiologic evidence suggests diets rich in
cruciferous vegetables, particularly broccoli, are
associated with lower bladder cancer risk.”

Molecular Nutrition and Food Research

https://www.ncbi.nlm.nih.gov/pubmed/23038615

Why are Cruciferous Vegetables so Beneficial?
“Isothiocyanates are a well-known class of cancer chemopreventive
agents, and broccoli sprouts are a rich source of several
isothiocyanates.”
“The incidence, multiplicity, size, and progression of bladder cancer
were all inhibited by the extract, while the extract itself caused no
histologic changes in the bladder. Moreover, inhibition of bladder
carcinogenesis by the extract was associated with significant
induction of glutathione S-transferase in the bladder, enzymes that
are important protectants against oxidants and carcinogens.”
“In conclusion, broccoli sprout extract is a highly promising
substance for bladder cancer prevention and the isothiocyanates in
the extract are selectively delivered to the bladder epithelium
through urinary excretion.”

Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/18310317

Sources of Isothiocyanate:
• Broccoli and broccoli sprouts
• Brussel sprouts
• Cauliflower
• Cabbage
• Arugula
• Watercress
•Horseradish
“Broccoli and broccoli sprouts have the highest amount
of the isothiocyanates”

Journal of Carcinogenesis

Vitamin B9- Folate and Bladder Cancer
“Dietary folate, a water-soluble B vitamin found in
a variety of fruits and vegetables, is of particular
interest as a chemopreventive agent due to its
role in DNA methylation and DNA synthesis and
repair.”
“In summary, high intake of dietary folate was
associated with an overall decrease in bladder
cancer risk.”
Sources of Vitamin B9 (Folate)
• Beans (Black Eyed Peas)
• Lentils
• Spinach
• Asparagus
• Lettuce (Cos or Romaine)
• Avocado
• Broccoli
• Tropical Fruits (Mango)
•Oranges

Nutrition and Cancer Journal

https://www.ncbi.nlm.nih.gov/pubmed/16573375

Vitamin D and Bladder Cancer
“This review consistently found strong inverse correlations with
solar UVB for 15 types of cancer: bladder, breast, cervical,
colon, endometrial, esophageal, gastric, lung, ovarian,
pancreatic, rectal, renal, and vulvar cancer; and Hodgkin's
and non-Hodgkin's lymphoma.”

Anticancer Research

https://www.ncbi.nlm.nih.gov/pubmed/22213311

“Vitamin D deficiency is associated with increased risk of bladder
carcinoma in present study.”

Cellular Physiology and Biochemistry

https://www.ncbi.nlm.nih.gov/pubmed/26545152

“Lower serum Vitamin D was associated with an increased risk of
bladder cancer.”

Biological Trace Element Research

https://www.ncbi.nlm.nih.gov/pubmed/20978193

Capsaicin and Bladder Cancer
“Capsaicin, the major pungent ingredient in genus
Capsicum, has recently been tried as an intravesical drug
for overactive bladder and it has also been shown to
induce apoptotic cell death in many cancer cells.”

Archives of Pharmacal Research

http://www.ncbi.nlm.nih.gov/pubmed/15595419

“Capsaicin induces cell death through increased reactive
oxygen species and decreased mitochondrial membrane
potential. Furthermore, capsaicin inhibits the
proliferation of bladder carcinoma.”

International Journal of Urology

https://www.ncbi.nlm.nih.gov/pubmed/22462738

Sources of Capsaicin
Capsaicin is present in peppers produced by certain pepper
plants (Capsicum frutescens)
•Cayenne, Green or Red chili, Spur or Tabasco
peppers
-These varieties of peppers contain about 198,000 parts per
million of capsaicin
Sweet Peppers contain Capsaicin in Lower Amounts
•Bell, Cherry, Cone, Green, Paprika
-These peppers contains 4,000 parts per million of
capsaicin

Conjugated Linoleic Acid (CLA) and Bladder Cancer
“CLA has been demonstrated to exert strong
anticarcinogenic effects in a variety of
experimental cancer models.”
“CLA inhibits cell proliferation and increases
programmed cell death in human bladder cancer
cells”

Journal of Medicinal Food

http://www.ncbi.nlm.nih.gov/pubmed/20136431

Sources of CLA
•Grass-fed Beef
•Raw Milk
•Eggs
•Grass-fed Butter

Turmeric (Curcumin) and Bladder Cancer
“Curcumin promotes apoptosis of bladder tumor cells.”

International Brazilian Journal of Urology

http://www.ncbi.nlm.nih.gov/pubmed/19860939

“Curcumin is a potent cytotoxic agent against the MBT and
UMUC bladder tumor cell lines. In addition, curcumin
effectively inhibits tumor implantation and growth.”

Journal of Urology

https://www.ncbi.nlm.nih.gov/pubmed/11547120

“Our results suggest that curcumin potentiates the antitumor
effect of BCG through the inhibition of NF-kappaB and induction
of TRAIL receptors in bladder cancer cells.”

Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/19903839

“Curcumin induces programmed cell death in human bladder cancer
cells”

Anticancer Drugs

https://www.ncbi.nlm.nih.gov/pubmed/16520656

“Curcumin (diferuloylmethane) is a natural compound that has been
known to possess anticancer properties in various cancers, including
bladder cancer.”

Cancer Prevention Research

https://www.ncbi.nlm.nih.gov/pubmed/21836020

“Curcumin, a polyphenol compound derived from Curcuma longa
Linn, has been recognized as a promising anti-cancer drug due to its
multiple properties including anti-inflammatory, antioxidant and anticarcinogenic
activities.”
“These observations suggest that curcumin may have therapeutic
potential for bladder cancer patients.”

Oncology Reports

http://www.ncbi.nlm.nih.gov/pubmed/16596191

Some Benefits of Curcumin
•Inhibit the proliferation of tumor cells
•Inhibit the transformation of cells from normal to tumor
• Help the body destroy mutated cancer cells so they
cannot spread throughout the body
• Decrease inflammation
• Help prevent the development of additional blood
supply necessary for cancer cell growth (angiogenesis)
Turmeric
“Turmeric (Curcuma longa), a commonly used spice
throughout the world, has been shown to exhibit antiinflammatory,
antimicrobial, antioxidant, and antineoplastic
properties.

Phytotherapy Research

https://www.ncbi.nlm.nih.gov/pubmed/20810543

Same as the previous postings. The video talk where the research comes from, along with more information and the slides with all the refeferences used for the talk.

https://www.youtube.com/watch?v=HbFBCxu7zdY